Post-Doc in Biochemistry or Biological Sciences in Dijon, France

The INSERM U866 Research Centre “Lipids, Nutrition, Cancer”

has an open position for

a Post-Doc

(PhD in Biochemistry or Biological Sciences)

For a transversal project in the INSERM Research Centre to improve the outcome

of cancer therapy by testing new potential treatments against human tumors (colon,

and breast cancer) with high level of efficacy and low toxicity.



Despite aggressive therapies, resistance of many tumors to established treatment

procedures still constitutes a major problem in cancer therapy. For example, the

therapeutic strategy of colorectal cancer is mainly based on surgery and a palliative

chemotherapy with 5-FU/folinic acid associated with Irinotecan.



However this strategy is not very successful, mainly due to establishment of a strong

resistance of cancer cells against the cytotoxic drugs, and to metastatic invasion.

The overall aim of the proposed transversal project in the INSERM U866 Unit “Lipids,

Nutrition, Cancer” is to evaluate: 1) the effect of polyphenols and new chemicals

analogues on the tumor cell plasma membrane, 2) and to determine novel cellular targets

in the cellular lipid metabolism which is implicated in the chemotherapeutic response and

in the Multi-Drug Resistance.



Disciplines: Biochemistry, Cellular and Molecular Biology



This project is part of a large scale program involving several teams in the INSERM Unit

Beside basis support from INSERM and French Ministery of research, this program is

supported by the “Conseil Régional de Bourgogne”, the vitivinicultural sector, the NACre

(Nutrition-Food Cancer research) network, the “Cancer League” (Côte d'Or committee) and

INCa (National Cancer Institute and Easter France Cancer cluster).



This position will be available in September-October 2010

and offers a competitive salary (2,500 euros per month).

General information on the INSERM U866 Research Center is available at:

http://www.u-bourgogne.fr/INSERM-U866/indexe.html

The INSERM Research Centre is situated in the University of Dijon, near the University

Hospital, with excellent communication facilities. Language spoken include English and

French. The INSERM Unit counts 10 teams with about 220 people and supported by 11

technical platforms (Cytometry, lipidomics, proteomics, metabolomics, RPE, …) in the

Research Federative Institute “Santé-Stic” (http://www.u-bourgogne.fr/IFR100/)

Curriculum vitae, name and contact details of two referees have to be sent to the

Supervisor of the Research Program by Email to

Dr. DELMAS Dominique (ddelmas@...)

INSERM Research Center “Lipids, Nutrition, Cancer”

Team 9 “Metabolic and Nutritional Laboratory”

University of Burgundy, Faculty of Sciences, 6 Bd Gabriel 21000 Dijon – FRANCE

Tel: +33 3 80 39 37 01 Continue Reading...

Postdoc biochemistry

Postdoc Biochemistry (1.0)
(Utrecht), 38 hours per week Utrecht University
 
Job description
Postdoc Biochemistry

Because pathogens become increasingly resistant to therapeutic drugs, and due to the emergence of new pathogens, novel approaches to the treatment of infectious diseases are required. By chemical cross-linking we have generated bifunctional proteins consisting of a lectin domain and a fragment of an antibody directed against Fc receptors on phagocytic cells. Studies in vitro in our laboratory have shown that such bifunctional proteins can stimulate uptake and killing of a broad spectrum of pathogens by recognizing the microbes through the lectin domain and targeting them to the phagocytes through the anti-Fc receptor part. Your task will be to expand this work by:

1) varying the anti-Fc receptor moiety
2) developing a method for the production of the bifunctional proteins
as fusion proteins
3) testing the effectiveness of the produced proteins with regard to
their stimulation of pathogen uptake and killing by phagocytes in
experiments in vitro. Depending on your affinity and experience, the
effectiveness can also be studied in mouse infection experiments in vivo.

Requirements
Doctorate
We are looking for a biochemist, or medical molecular biologist,
holding a PhD degree, who has experience with molecular biology, protein
expression, various protein purification techniques and cell culture, and
who has affinity with immunology. Candidates from the European Union are
eligible for this position. Applications from the American continent
will also be considered.



Organization
Utrecht University
Faculty of Veterinary Medicine
The Faculty of Veterinary Medicine www.vet.uu.nl is an internationally
leading institute in veterinary scientific education, research and
associated patient care. It ranks number one in Europe and among the top
five institutes of veterinary science world-wide and is accredited by the
American Medical Veterinary Association and the Canadian Medical
Veterinary Association.

The Department of Biochemistry and Cell Biology invites applications
for a


Postdoc Biochemistry

Conditions of employment
Estimated maximum salary per month: eur 3500 - 4000
Salaryscale 10.
Maximum salary amount in Euro's a month 3755
Employment basis: Temporary for specified period
Duration of the contract: 2 years
Maximum hours per week: 38

Additional conditions of employment:
We offer an experienced, collaborative and international group of
colleagues and an excellent infrastructure that integrates molecular
biology, biochemistry, life-cell imaging, and a state of the arts lipidomics
facility. We take part in the Institute of Biomembranes
www.biomembranes.nl the Academic Biomedical Centre www.abc.uu.nl and are engaged in
many (inter)national collaborations.
We offer a fulltime temp. app. for 2 years.
Your gross salary will amount between € 2,861.- and € 3,755,- per
month (full-time appointment in scale 10 of the Collective Labour
Agreement of the Dutch Univ.), depending on previous qualifications and
experience. Salaries are supplemented with a holiday bonus of 8% and a
year-end bonus of 8,3% per year. There are outstanding secondary benefits,
based on the CAO of NL Univ. and include e.g. a min. of 29 days holiday
per year, an arrangement for study fac., generous contributions to
healthcare, childcare, a pension scheme and flexible employment conditions.

Additional Information
Additional information about the vacancy can be obtained from:

Dr. J.J. Batenburg
Telephone number: +31 (0)30 253 5381
E-mail address: j.j.batenburg@uu.nl

Or additional information can be obtained through one of the following
links.

   * About the organization


Application
You can apply for this job before 03-01-2009 by sending your
application to:

The Faculty of Veterinary Medicine
Personnel department
M.E.J. Willemse-van Soest
Yalelaan 1
NL 3584 CL Utrecht

E-mail address: vacatures1@vet.uu.nl

Please send your application (including a cover letter, a CV, a statement of education, research interests and experimental methods used, and a detailed list of publications and achievements), accompanied by the names and contact info of persons who are able to provide professional reference.

When applying for this job always mention the vacancy number 12896.

The short URL code for this job opening is: 00351-1787.
You can use this as a direct link to the job by adding the code to the
URL www.academictransfer.org/ 

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