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Friday, April 11, 2008

Post-Doctoral Fellowship Modelling of Cardiovascular Safety (full time) Leiden University, Leiden, The Netherlands

Post-Doctoral Fellowship
Modelling of Cardiovascular Safety (full time)
Leiden University, Leiden, The Netherlands

Job description
TOP Institute Pharma (TI Pharma) has granted ourproposal to set up a mechanism-based PKPD modelling platform. This platformfocuses on the transfer of knowledge from academia to the pharmaceuticalindustry and is a collaborative effort of four excellent academic institutes andsix leading global pharmaceutical industries. Unique to this platform is theavailability of shared databases on disease and drug related parameters.

The aim ofthe platform is to provide a scientific basis for rational drug discovery anddevelopment with a strong focus on priority medicines. In total 11 PhD students and 7 post-doctoralfellows are employed by the platform. Three working groups have been establishedwhich will address the following challenges 1) to develop mechanism-based PKPDmodels to characterise disease progression, 2) to predict the effects of ageingon clinical response and 3) to create a translational research framework thatallows extrapolation of preclinical to clinical and epidemiological findings.The approach is based on hierarchical models and relies on the use of advanced statisticalsoftware tools such as NONMEM, WINBUGS and R.

To ensure thedevelopment of a conceptual research framework beyond the specific scientificquestions being addressed by the working groups and enable cross-fertilisation ofskills, a position has been created for a post doctoral fellow. The main objective of this program is toevaluate how cardiovascular safety findings in phase IIIclinical trials correlate to long term safety in longitudinal (epidemiology)studies. From a methodological perspective, this investigation is aimed atevaluating new parameterisations for drug exposure and integration of PKPDconcepts into the assessment of risk.

Requirements
The post-doctoralfellow should have the following background and competencies:
· Astrong background in statistical modelling & simulation and/or Bayesianstatistics
· Adegree in Biostatistics, Epidemiology, Medicine, Biopharmaceutical Sciences, Physiology orequivalent scientific training
· Birdeyes¢ view
· Conceptualthinker
· Problem-solvingand coaching skills are essential
· Ambitious
· Creative
· Interested to perform research in a unique multidisciplinary setting

Organisation

The Leiden Division ofPharmacology at the Leiden/Amsterdam Center for Drug Research (LACDR) has along-standing expertise in the development of Pharmacokinetic/Pharmacodynamic(PKPD) models to predict efficacy and safety of drugs. Given the nature of thisproject, the main task of the principal post-doctoral fellow will be to coachthe PhD students and postdocs within the platform, to support model buildingand simulation and to identify underlying general principles shared amongindividual projects.

Conditions of employment

Theemployment for this position will be full time for 4 years.

Additional conditions of employment:
You will workas a team member of a TI Pharma project. The project team comprises academicand industrial partners. In this case, the partners are: University of Leiden,University of Groningen,the University Medical Center of Utrecht, the ErasmusMedical Center,Rotterdam and thecompanies Eli Lilly, Johnson & Johnson, GSK, Nycomed, Organon/Schering Plough and Pfizer. You willattend a unique drug discovery education and training program offered by TIPharma.
Additional Information
Additional information can be obtained through one of
the following links:
http://www.lacdr.nl
Application

Youcan apply by sending your application to:
Contactperson
Dr. O. Della Pasqua
Division of Pharmacology, Leiden/Amsterdam Center forDrug Research
Leiden, TheNetherlands
Odp72514@gsk.com
+44 7876031907

The way to AMINEF in Gedung Balai Pustaka

American Indonesian Exchange Foundation
Balai Pustaka Building, 6th. Floor
Jl. Gunung Sahari Raya No. 4
Jakarta 10720, Indonesia

1. The buses which goes to Senen Bus Station all of them pass through Gedung Balai Pustaka. Especially which route is through Pasar Baru .

2. Bus Transjakarta, from Blok M you have to change the bus 2-3 times.
Way 1 : from Blok M change the bus in Dukuh Atas bus stop to the bus towards Pulogadung, then take a bus in Pramuka bus stop towards Ancol, this bus pass through Gedung Balai Pustaka. The closest bus stop (Budi Utomo) is about 800 meters from Gedung Balai .
Way 2 : From Blok M take the bus in the Harmoni Bus Stop, the bus towards Pulogadung, get down in Senen Bus Stop and walk about 800 meters, or from this bus stop take the bus towards Ancol and get down as mentioned in way 1. About the distance, this two bus stops is about the same. (It is better if you take ojek or bajaj from this bus stop to Gedung Balai Pustaka)

3. If you take taxi with old tariff (TL=Tarif Lama) from blok M with no traffic jam is about Rp. 30.000,00.

4. From Blok M use bus Patas AC 76. Gedung Balai Pustaka is in the right side, after you pass through Depag, and say to conductor "Balai Pustaka"

5. Use a busway from Blok M towards Kota, get down in Sawah Besar bus stop. From here take a Mikrolet M12 towards Senen. After cross road Wahidin and before senen get down and cross the street.

Living Cost in Germany

Living Cost in Germany is vary from city to city, but this is th case if you stay in Aachen, Germany
Student accommodation or private sharing : 180 - 230 euros per month
Food : 10 - 12 euros per day (if eating outside)
Transport for students : free within Aachen and until Koln and Dusseldorf in regional trains)

Living Cost In Austria

Living Cost in Austria is depending on the city, for example the Capital of Austria, Vienna:
- Dormitory is about 250-400 euro per month.
- Living Cost 200-400 euro per month.
- Transportation 128 euro per 4 months (student and age < 26), or 49 euro per month (ordinary)

For visa, it has to be a letter from the University/Scholl in Austria. It takes about 2-3 months.

Where to do GMAT Test

GMAT Tests are held in Jakarta, Indonesia :
1. EEC Slipi +62-21 5320044 or +62-215323176
2. Kaplan GMAT Preparation +62-81388908450, +62-21 5211588, +62-215211701 (Information abaout this test can be asked in that number)
3. Or this number +62-213159225

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