PhD researcher Immunopharmacology (1.0 fte)
(Utrecht), 38 hours per week
Utrecht University Job descriptionPhD researcher Immunopharmacology
Excessive innate
immune responses might be responsible for exacerbations of disturbed adaptive immunity associated with
COPD and asthma. The targets in this PhD-project entitled “TLR–expression, stimulation and inhibition in asthma and COPD” are
Toll like receptors, since they are the sentinels of the
innate immune system. In these diseases impairment and polymorphisms of TLRs have been described abundantly. The main goal will be to unravel the importance of TLR in asthma and COPD.
Translational medicine experiments will be performed in vivo and in vitro on immune cells in close collaboration with a Post Doc.:
optimizing different in vivo models for COPD and asthma
assessment of TLR expression in airways and inflammatory cells in health and disease
testing of pre- and probiotics and new chemical entities interfering with TLRs.
You will work as a team member of the TI Pharma project D1.101 Exploiting Toll like receptors for
drug discovery. The project team comprises academic and industrial partners. In this case, the partners are: universities of Leiden, Utrecht, Maastricht and Nijmegen, the institute TNO and the biopharmaceutical companies Danone,
Schering Plough and ISA Pharmaceuticals. You will attend a unique
drug discovery education and training program offered by TI Pharma.
Requirements
University Graduate
We are looking for a candidate with
a master's degree (MSc) or an equivalent in
Biomedical Sciences,
Pharmaceutical Sciences or Medical Sciences;
experience with
cell culture, RT-PCR, immunohistochemistry,
FACS analysis and ELISA;
affinity with in vivo disease models;
permission to work with laboratory animals (Artikel 9 bevoegdheid; Wet op de Dierproeven), or the willingness to acquire the necessary qualification;
excellence in intellectual curiosity and a results- and performance-driven mind-set;
ambition and creativeness;
an interest in performing research in a unique multidisciplinary setting.
Additional information about the job:
Research at the Division of Pharmacology and
Pathophysiology deals mainly with the immunopharmacology of the respiratory and
gastrointestinal system. The objective of this program is to gain deeper insight into the ways in which cells and mediators of the immune system contribute to the malfunctioning of the respiratory and gastrointestinal system in animals and humans. A better understanding may lead to improvement of current therapy and to new therapy strategies. The program takes an integrative approach from ‘molecular’ to ‘in vivo ’research.
The division Pharmacology & Pathophysiology is participating in a TIPharm-funded platform “Exploiting Toll like receptors for drug discovery”. This TLR-platform joins top scientists and industry, working together on TLRs.
PhD researcher Immunopharmacology
OrganizationUtrecht UniversityFaculty of Science
The new Faculty of Science consists of six departments: Biology, Pharmaceutical Sciences, Information and
Computing Sciences, Physics and Astronomy, Chemistry and Mathematics.
The Faculty is home to 3500 students and nearly 2000 staff and is internationally renowned for the quality of its research. The Faculty's academic programmes reflect developments in today's society.
The Pharmaceutical Sciences are concerned with the discovery, development, and use of medicines. The mission of scientists
working in the field is to ensure that new medications are both better and safer than our present pharmacotherapeutic arsenal for life-threatening diseases such as cancer and
AIDS but also chronic illnesses that affect the quality of life, such as asthma, arthritis, and mental or psychiatric disorders.
The Pharmaceutical Sciences are multidisciplinary in nature. They draw upon work in the fields of
molecular biology and biotechnology, genomics, (bio)chemistry,
analytical chemistry, and the (veterinary) medical sciences. These contributing disciplines are now in a dynamic phase, generating new insights and a wealth of new technologies as they grow.
Conditions of employment
Estimated maximum salary per month: eur 2500 - 3000
Salaryscale 10.
Maximum salary amount in Euro's a month 2612
Employment basis: Temporary for specified period
Duration of the contract: 4 years
Maximum hours per week: 38
Additional conditions of employment:
The candidate is offered a full-time position for 4 years.
Gross salary starts with € 2,042 per month in the first year and increases to € 2,612 in the fourth year of employment.
The salary is supplemented with a holiday bonus of 8% and an end-of-year bonus of 8.3% per year. In addition we offer: a
pension scheme, a partially paid parental leave, flexible employment conditions in which you may trade salary for vacation days or vice versa. Conditions are based on the Collective Employment Agreement of the
Dutch Universities. The research group will provide the candidate with necessary support on all aspects of the project.
Additional Information
Additional information about the vacancy can be obtained from:
Dr Aletta Kraneveld
Telephone number: +31 (0) 30 253 4509
Prof Dr Gert Folkerts
Telephone number: 31 (0) 30 253 7353
Or additional information can be obtained through one of the following links.
* About the organization
Application
You can apply for this job before
13-12-2008 by sending your application to:
Faculty of Science
Personnel department
PO Box 80010
3508 TA Utrecht
The Netherlands
E-mail address:
Science.Peno@uu.nlPlease send your application including a letter of motivation, curriculum vitae and contact details of at least two references.
When applying for this job always mention the vacancy number 67807.
The short URL code for this job opening is: 00351-1775.
You can use this as a direct link to the job by adding the code to the URL
www.academictransfer.org/ 
