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Thursday, November 27, 2008

PhD researcher Immunopharmacology

PhD researcher Immunopharmacology (1.0 fte)
(Utrecht), 38 hours per week Utrecht University

Job description
PhD researcher Immunopharmacology
Excessive innate immune responses might be responsible for exacerbations of disturbed adaptive immunity associated with COPD and asthma. The targets in this PhD-project entitled “TLR–expression, stimulation and inhibition in asthma and COPD” are Toll like receptors, since they are the sentinels of the innate immune system. In these diseases impairment and polymorphisms of TLRs have been described abundantly. The main goal will be to unravel the importance of TLR in asthma and COPD. Translational medicine experiments will be performed in vivo and in vitro on immune cells in close collaboration with a Post Doc.:
optimizing different in vivo models for COPD and asthma
assessment of TLR expression in airways and inflammatory cells in health and disease
testing of pre- and probiotics and new chemical entities interfering with TLRs.
You will work as a team member of the TI Pharma project D1.101 Exploiting Toll like receptors for drug discovery. The project team comprises academic and industrial partners. In this case, the partners are: universities of Leiden, Utrecht, Maastricht and Nijmegen, the institute TNO and the biopharmaceutical companies Danone, Schering Plough and ISA Pharmaceuticals. You will attend a unique drug discovery education and training program offered by TI Pharma.

Requirements
University Graduate
We are looking for a candidate with
a master's degree (MSc) or an equivalent in Biomedical Sciences, Pharmaceutical Sciences or Medical Sciences;
experience with cell culture, RT-PCR, immunohistochemistry, FACS analysis and ELISA;
affinity with in vivo disease models;
permission to work with laboratory animals (Artikel 9 bevoegdheid; Wet op de Dierproeven), or the willingness to acquire the necessary qualification;
excellence in intellectual curiosity and a results- and performance-driven mind-set;
ambition and creativeness;
an interest in performing research in a unique multidisciplinary setting.



Additional information about the job:
Research at the Division of Pharmacology and Pathophysiology deals mainly with the immunopharmacology of the respiratory and gastrointestinal system. The objective of this program is to gain deeper insight into the ways in which cells and mediators of the immune system contribute to the malfunctioning of the respiratory and gastrointestinal system in animals and humans. A better understanding may lead to improvement of current therapy and to new therapy strategies. The program takes an integrative approach from ‘molecular’ to ‘in vivo ’research.

The division Pharmacology & Pathophysiology is participating in a TIPharm-funded platform “Exploiting Toll like receptors for drug discovery”. This TLR-platform joins top scientists and industry, working together on TLRs.


PhD researcher Immunopharmacology

Organization
Utrecht University
Faculty of Science
The new Faculty of Science consists of six departments: Biology, Pharmaceutical Sciences, Information and Computing Sciences, Physics and Astronomy, Chemistry and Mathematics. The Faculty is home to 3500 students and nearly 2000 staff and is internationally renowned for the quality of its research. The Faculty's academic programmes reflect developments in today's society.

The Pharmaceutical Sciences are concerned with the discovery, development, and use of medicines. The mission of scientists working in the field is to ensure that new medications are both better and safer than our present pharmacotherapeutic arsenal for life-threatening diseases such as cancer and AIDS but also chronic illnesses that affect the quality of life, such as asthma, arthritis, and mental or psychiatric disorders.
The Pharmaceutical Sciences are multidisciplinary in nature. They draw upon work in the fields of molecular biology and biotechnology, genomics, (bio)chemistry, analytical chemistry, and the (veterinary) medical sciences. These contributing disciplines are now in a dynamic phase, generating new insights and a wealth of new technologies as they grow.

Conditions of employment
Estimated maximum salary per month: eur 2500 - 3000
Salaryscale 10.
Maximum salary amount in Euro's a month 2612
Employment basis: Temporary for specified period
Duration of the contract: 4 years
Maximum hours per week: 38

Additional conditions of employment:
The candidate is offered a full-time position for 4 years.

Gross salary starts with € 2,042 per month in the first year and increases to € 2,612 in the fourth year of employment.

The salary is supplemented with a holiday bonus of 8% and an end-of-year bonus of 8.3% per year. In addition we offer: a pension scheme, a partially paid parental leave, flexible employment conditions in which you may trade salary for vacation days or vice versa. Conditions are based on the Collective Employment Agreement of the Dutch Universities. The research group will provide the candidate with necessary support on all aspects of the project.

Additional Information
Additional information about the vacancy can be obtained from:

Dr Aletta Kraneveld
Telephone number: +31 (0) 30 253 4509

Prof Dr Gert Folkerts
Telephone number: 31 (0) 30 253 7353

Or additional information can be obtained through one of the following links.

* About the organization


Application
You can apply for this job before 13-12-2008 by sending your application to:

Faculty of Science
Personnel department
PO Box 80010
3508 TA Utrecht
The Netherlands
E-mail address: Science.Peno@uu.nl

Please send your application including a letter of motivation, curriculum vitae and contact details of at least two references.

When applying for this job always mention the vacancy number 67807.

The short URL code for this job opening is: 00351-1775.
You can use this as a direct link to the job by adding the code to the URL www.academictransfer.org/

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The way to AMINEF in Gedung Balai Pustaka

American Indonesian Exchange Foundation
Balai Pustaka Building, 6th. Floor
Jl. Gunung Sahari Raya No. 4
Jakarta 10720, Indonesia

1. The buses which goes to Senen Bus Station all of them pass through Gedung Balai Pustaka. Especially which route is through Pasar Baru .

2. Bus Transjakarta, from Blok M you have to change the bus 2-3 times.
Way 1 : from Blok M change the bus in Dukuh Atas bus stop to the bus towards Pulogadung, then take a bus in Pramuka bus stop towards Ancol, this bus pass through Gedung Balai Pustaka. The closest bus stop (Budi Utomo) is about 800 meters from Gedung Balai .
Way 2 : From Blok M take the bus in the Harmoni Bus Stop, the bus towards Pulogadung, get down in Senen Bus Stop and walk about 800 meters, or from this bus stop take the bus towards Ancol and get down as mentioned in way 1. About the distance, this two bus stops is about the same. (It is better if you take ojek or bajaj from this bus stop to Gedung Balai Pustaka)

3. If you take taxi with old tariff (TL=Tarif Lama) from blok M with no traffic jam is about Rp. 30.000,00.

4. From Blok M use bus Patas AC 76. Gedung Balai Pustaka is in the right side, after you pass through Depag, and say to conductor "Balai Pustaka"

5. Use a busway from Blok M towards Kota, get down in Sawah Besar bus stop. From here take a Mikrolet M12 towards Senen. After cross road Wahidin and before senen get down and cross the street.

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Student accommodation or private sharing : 180 - 230 euros per month
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