Principal Post-Doctoral Fellow
PKPD modelling platform (full time)
Leiden University, Leiden, The Netherlands
Job description
TOP Institute Pharma (TI Pharma) has granted ourproposal to set up a mechanism-based PK-PD modelling platform. This platformfocuses on the transfer of knowledge from academia to the pharmaceuticalindustry and is a collaborative effort of four excellent academic institutes andsix leading global pharmaceutical industries. Unique to this platform is theavailability of shared databases on disease and drug related parameters.
The aim ofthe platform is to provide a scientific basis for rational drug discovery anddevelopment with a strong focus on priority medicines. In total 11 PhD students and 7 post-doctoralfellows are employed by the platform. Three working groups have been establishedwhich will address the following challenges 1) to develop mechanism-based PK-PDmodels to characterise disease progression, 2) to predict the effects of ageingon clinical response and 3) to create a translational research framework thatallows extrapolation of preclinical to clinical and epidemiological findings.The approach is based on hierarchical models and relies on the use of advanced statisticalsoftware tools such as NONMEM, WINBUGS
and R.
To ensure the development of a conceptual researchframework beyond the specific scientific questions being addressed by theworking groups and enable cross-fertilisation of skills, a position has beencreated for a principal post doctoralfellow. This appointment also offersthe possibility for a tenure track into an academic career.
Requirements
The post-doctoralfellow should have the following background and competencies:
· Astrong background in PK-PD modelling & simulation and/or Bayesianstatistics
· Adegree in Biostatistics, Medicine, Bioengineering, Biopharmaceutical Sciences,Physiology or equivalent scientific training
· Birdeyes¢ view
· Conceptualthinker
· Problem-solvingand coaching skills are essential
· Ambitious
· Creative
· Interested to perform research in a unique multidisciplinary setting
Organisation
The Leiden Division ofPharmacology at the Leiden/Amsterdam Center for Drug Research (LACDR) has along-standing expertise in the development of Pharmacokinetic/Pharmacodynamic(PK-PD) models to predict efficacy and safety of drugs. Given the nature ofthis project, the main task of the principal post-doctoral fellow will be to coachthe PhD students and postdocs within the platform, to support model buildingand simulation and to identify underlying general principles shared amongindividual projects.
Conditions of employment
Theemployment for this position will be full time for 4 years.
Additional conditions of employment:
You will workas a team member of a TI Pharma project. The project team comprises academicand industrial partners. In this case, the partners are: University of Leiden,University of Groningen,the University Medical Center of Utrecht, the ErasmusMedical Center,Rotterdam and thecompanies Eli Lilly, Johnson & Johnson, GSK, Nycomed, Organon/Schering Plough and Pfizer. You willattend a unique drug discovery education and training program offered by TIPharma.
Additional Information
PKPD modelling platform (full time)
Leiden University, Leiden, The Netherlands
Job description
TOP Institute Pharma (TI Pharma) has granted ourproposal to set up a mechanism-based PK-PD modelling platform. This platformfocuses on the transfer of knowledge from academia to the pharmaceuticalindustry and is a collaborative effort of four excellent academic institutes andsix leading global pharmaceutical industries. Unique to this platform is theavailability of shared databases on disease and drug related parameters.
The aim ofthe platform is to provide a scientific basis for rational drug discovery anddevelopment with a strong focus on priority medicines. In total 11 PhD students and 7 post-doctoralfellows are employed by the platform. Three working groups have been establishedwhich will address the following challenges 1) to develop mechanism-based PK-PDmodels to characterise disease progression, 2) to predict the effects of ageingon clinical response and 3) to create a translational research framework thatallows extrapolation of preclinical to clinical and epidemiological findings.The approach is based on hierarchical models and relies on the use of advanced statisticalsoftware tools such as NONMEM, WINBUGS
and R.
To ensure the development of a conceptual researchframework beyond the specific scientific questions being addressed by theworking groups and enable cross-fertilisation of skills, a position has beencreated for a principal post doctoralfellow. This appointment also offersthe possibility for a tenure track into an academic career.
Requirements
The post-doctoralfellow should have the following background and competencies:
· Astrong background in PK-PD modelling & simulation and/or Bayesianstatistics
· Adegree in Biostatistics, Medicine, Bioengineering, Biopharmaceutical Sciences,Physiology or equivalent scientific training
· Birdeyes¢ view
· Conceptualthinker
· Problem-solvingand coaching skills are essential
· Ambitious
· Creative
· Interested to perform research in a unique multidisciplinary setting
Organisation
The Leiden Division ofPharmacology at the Leiden/Amsterdam Center for Drug Research (LACDR) has along-standing expertise in the development of Pharmacokinetic/Pharmacodynamic(PK-PD) models to predict efficacy and safety of drugs. Given the nature ofthis project, the main task of the principal post-doctoral fellow will be to coachthe PhD students and postdocs within the platform, to support model buildingand simulation and to identify underlying general principles shared amongindividual projects.
Conditions of employment
Theemployment for this position will be full time for 4 years.
Additional conditions of employment:
You will workas a team member of a TI Pharma project. The project team comprises academicand industrial partners. In this case, the partners are: University of Leiden,University of Groningen,the University Medical Center of Utrecht, the ErasmusMedical Center,Rotterdam and thecompanies Eli Lilly, Johnson & Johnson, GSK, Nycomed, Organon/Schering Plough and Pfizer. You willattend a unique drug discovery education and training program offered by TIPharma.
Additional Information
Additional information can be obtained through one of
the following links:
http://www.lacdr.nl
Application
Youcan apply by sending your application to:
Contactperson
Dr. O. Della Pasqua
Division of Pharmacology, Leiden/Amsterdam Center forDrug Research
Leiden,The Netherlands
Odp72514@gsk.com
+44 7876031907
